I've pruned Google Reader before, and it's always been a relief afterwards. I need to remember to do it more regularly. I don't want to stop using an RSS reader all together, but I do want to better moderate my usage of it. I want to perhaps use it more just for friends or occasional and interesting sources.
So no more Engadget (feel free to send me interesting articles, as I might not hear about them elsewise), no more tumblrs for my favourite YouTubers (I'll have to live just watching you in video form), and fewer science sites (fascinating, but not applicable to my own fields of main interest).